Which medication is not compatible with normal saline (NS)?

Amphotericin B is known to have compatibility issues with normal saline (NS) due to its lipid composition and solubility characteristics. Amphotericin B can precipitate out of solution when mixed with normal saline, leading to a cloudy appearance and potential ineffectiveness of the drug. This incompatibility can also increase the risk of adverse effects if the precipitate is administered to a patient.

In contrast, the other choices listed have different compatibility profiles. Daptomycin, Heparin, and various chemotherapy agents can often be mixed with normal saline under certain conditions, although individual drug compatibility can depend on specific formulations and circumstances. Therefore, Amphotericin B stands out as the medication that is not compatible with normal saline, highlighting the importance of understanding the stability and compatibility of medications in sterile compounding.