When should the ISO Class 5 Primary Engineering Control (PEC) be cleaned?

Cleaning the ISO Class 5 Primary Engineering Control (PEC) at the beginning of each shift and before each batch is essential for maintaining a sterile compounding environment. The PEC, such as a laminar airflow hood or isolator, plays a critical role in protecting compounded sterile preparations from airborne contaminants.

Cleaning at these times ensures that the surface is free from any potential contaminants that may have accumulated from previous use or from the surrounding environment. It is vital to perform this cleaning prior to starting the compounding process to prevent the risk of contamination during the preparation of sterile products.

Comprehensive cleaning protocols that include these intervals help in enhancing safety and compliance with regulatory standards. This practice is not just a routine; it is a fundamental part of aseptic techniques and ensures that the integrity of sterile preparations is preserved throughout the compounding process.