Incompatibility of which antibiotic with D5W is specifically noted?

Daptomycin is known for its incompatibility with D5W (5% dextrose in water). This incompatibility arises due to the chemical properties of daptomycin, which can lead to precipitation when mixed with dextrose solutions. Incompatibility in this context means that when the drug is mixed with the solution, it does not remain in a stable or bioavailable form, which can compromise its efficacy and could potentially harm the patient if administered in a compromised state.

Amphotericin B has specific handling and reconstitution requirements, and while it has its own set of compatibility issues, it is typically not noted for incompatibility specifically with D5W. Ciprofloxacin and penicillin also have compatibility considerations, but do not exhibit the same level of concern regarding their interaction with D5W as daptomycin does. Understanding these compatibility issues is crucial for safe medication preparation and administration in sterile compounding environments.